MSE410 : Design and Applications of Biomaterials
Biomaterials and their physiological interactions. Materials used in medicine/dentistry: metals, ceramics, polymers, composites, resorbable, smart, natural materials. Material response/degradation: mechanical breakdown, corrosion, dissolution, leaching, chemical degradation, wear. Host responses: foreign body reactions, inflammation, wound healing, carcinogenicity, immunogenicity, cytotoxicity, infection, local/systemic effects.
Textbook: Ratner, B. D.; Hoffman, A. S.; Schoen, F. J.; Lemons, J. E., 2nd Eds, Biomaterials Science: An Introduction to Materials in Medicine, Elsevier Academic Press, 2004.
Cognizant Faculty: Takayama, Kim, Lahann
- Design parameters applicable to biomaterials
- Reconstructive materials used in medicine and dentistry (metals, ceramics, polymers, and composites)
- Regenerative materials used in medicine and dentistry (bioresorbable materials, films/coatings, smart materials, natural materials, biologically functional materials)
- Material response - material degradation in-vivo (deformation/mechanical breakdown, corrosion, dissolution/leaching, chemical degradation, friction/wear)
- Host responses (foreign body reactions, inflammation, histological/hematological considerations, wound healing, carcinogenicity, immunogenicity, cytotoxicity, infection, local and systemic effects)
- Methods of testing material performance (in-vitro and in-vivo methods and models, standardization and retrieval analysis)
- Design principles for individual applications (biocompatibility, mechanical properties, cell adhesion properties, protein adhesion properties)
- To teach students the interdisciplinary issues involved in biomaterials design, synthesis, evaluation and analysis, so that they may pursue higher-level, more focused to graduate courses in biomaterials, address research problems, or pursue a job-search in the medical device industry
- To teach students the basic classes of reconstructive biomaterials and how these materials differ from similar classes of materials used in other industries
- To teach students the basic classes of regenerative biomaterials and how combinations of materials and biological moieties may be used in combination to orchestrate a desired physiological response
- To teach students mechanisms of material degradation in-vivo and how to apply these concepts to biomaterials design and analysis
- To teach students mechanisms of host responses to biomaterials so that these concepts may be used to design and evaluate new and existing biomaterials
- To provide students with a greater familiarity with the biomaterials research literature
- To provide some training in critical thinking and analysis
- To provide some training in (written and oral) communication of scientific and engineering ideas
- Given a clinical problem involving lost tissue structure and function, students should be able to express a range of potential biomaterial treatments options, including synthetic and/or biological strategies.
- Given a biomaterial design problem, students should be able to outline all parameters needed to optimize the design.
- Given a specific biomaterial, students should be able to identify the advantages and disadvantages of this material in terms of its material degradation and host response.
- Given a specific organ/tissue system in need of reconstruction or regeneration, students should be able to identify appropriate candidate materials and an appropriate time frame of service-life.
- Given a specific biomaterial, students should be able to identify the important biological responses of potential importance.
- Biweekly, problem sets to test objectives 1) - 5) for individual students (50/450 points)
- In class three closed-book exams to test objectives 1) - 5) for individual students Ð focus on design principles of biomaterials and related biological events (150/450 points)
- In class 10-minutes presentation on a freely chosen paper related course topics to test objectives 1) Ð 5) and help students to develop critical journal reading ability (50-/450)
- A written proposal and an in-class presentation of a research idea on biomaterial development to test assignment to test objectives 1-5 for groups of students - define a problem in biomaterials, pose research questions/hypotheses and methodologies to address this problem, and write a research proposal to address this question (150/450)
- In class participation to encourage interactive discussions (50/450).